Meso Scale Discovery Services
Meso Scale Discovery (MSD) is an analytical technology analogous to ELISA but employs electrochemiluminescence as the detection method. It provides high sensitivity, excellent reproducibility, and a broad dynamic range, enabling the simultaneous quantification of multiple biomarkers from small sample volumes. At Avance Biosciences, our expert scientific team utilizes MSD to analyze single or multiplexed analytes, supporting non-clinical and clinical PK/PD studies, biomarker profiling, and immunogenicity testing.
Our Expertise
Drawing on our extensive expertise in custom immunoassay development, validation, and sample testing, we specialize in delivering tailored solutions that meet the unique requirements of our clients. By harnessing the capabilities of MSD’s versatile MESO QuickPlex SQ 120MM instrument and drawing on our extensive immunoassay expertise, we are strongly positioned to facilitate assays across drug product manufacturing, preclinical GLP studies, and clinical GLP settings.
Selected Applications:
Application
Description
Immunogenicity Testing
MSD is used for detecting and quantifying anti-drug antibodies (ADA) in response to biologic therapies. It enables sensitive and specific measurement of ADA, which is critical for assessing potential immune responses and safety profiles.
PK/PD Studies
MSD facilitates pharmacokinetic (PK) and pharmacodynamic (PD) assessments in preclinical and clinical studies of biologics. It enables precise quantification of drug concentrations and biomarker responses, aiding in dose optimization and efficacy evaluations.
Biomarker Profiling
MSD is used for multiplexed analysis of biomarkers in biologics research and development. It allows simultaneous measurement of multiple analytes, such as cytokines, growth factors, and cell surface markers, to characterize disease pathways, monitor treatment responses, and identify predictive biomarkers.
Quality Control in Manufacturing
MSD can be used in quality control during biologics manufacturing. It ensures batch-to-batch consistency by verifying protein concentrations, assessing purity, and detecting impurities or contaminants in the final product.