Enzyme-Linked Immunosorbent Assay Services
Enzyme-Linked Immunosorbent Assay (ELISA) is a widely used analytical technique to detect and quantify specific proteins, antibodies, and other biomolecules with high sensitivity and precision. ELISA’s versatility makes it indispensable in research, diagnostics, and drug development, providing essential data for understanding disease mechanisms, monitoring treatment efficacy, and advancing therapeutic innovations. Avance Biosciences provides comprehensive CGMP/GLP-compliant ELISA services that are tailored to meet the diverse needs of your projects, from early-stage research to clinical trials and quality control.
Our Expertise
Avance Biosciences scientific team brings together decades of collective experience in immunoassays. Leveraging our expertise in custom immunoassay development, validation, and sample testing, we specialize in delivering tailored solutions that meet both client and regulatory requirements. Our capabilities are enhanced by the advanced BioTek Cytation 5 platform, enabling versatile detection methods such as fluorescence, luminescence, UV-Vis absorbance, and time-resolved fluorescence.
Selected Applications:
Application
Description
Quantification of Therapeutic Proteins
ELISA is pivotal in drug development for quantifying therapeutic proteins in biological samples, providing essential pharmacokinetic (PK) data necessary for understanding drug absorption, distribution, metabolism, and excretion (ADME).
Immunogenicity Testing
ELISA is used in assessing the immunogenicity of biologic drugs by detecting and quantifying anti-drug antibodies (ADAs). This helps evaluate potential immune responses that may impact drug efficacy and safety.
Biomarker Analysis
ELISA enables the measurement of disease-specific biomarkers in clinical samples, aiding in the identification and validation of potential biomarkers for patient stratification and monitoring treatment response.
Quality Control (QC)
In drug manufacturing, ELISA is utilized for QC purposes to ensure batch-to-batch consistency and to verify the presence and concentration of key components in biologic formulations.
Detection of Residual Host Cell Proteins (HCPs)
During biopharmaceutical production, ELISA is employed to detect residual HCPs in drug formulations, ensuring product purity and safety.