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Biomarker Analysis Services for Clinical Trials

Biomarker testing is crucial in clinical trials as it identifies molecular indicators of disease presence and progression, aids in patient stratification by predicting treatment responses, and enhances the selection of participants likely to benefit from specific therapies. It monitors biomarker levels to assess treatment efficacy and provides early indicators of therapeutic success. Additionally, biomarker testing discovers markers indicative of adverse effects, helping to ensure patient safety. By analyzing biomarkers, clinical trials can improve precision medicine approaches, leading to more targeted and effective treatments.

Our Expertise

At Avance Biosciences, we specialize in a wide range of advanced technologies essential for biomarker analysis in clinical trials. Our expertise includes gene expression analysis, genotyping, and protein analysis, providing detailed insights into genetic and protein biomarkers. We offer comprehensive metabolomics and epigenetic analysis, as well as immunoassays and cytogenetics for enhanced biomarker discovery. Additionally, our skills in flow cytometry enable precise cell characterization, while our microbiome analysis provides a holistic view of microbial diversity. This broad technological proficiency ensures accurate and comprehensive biomarker analysis, driving success in clinical trials.

Biomarker Analysis Services for Clinical Trials

Service

Purpose

Technology

Gene Expression

Identifies gene expression biomarkers for predicting treatment outcomes, monitoring treatment efficacy, and understanding disease pathways.

  • RNA sequencing (RNA-seq)

  • Real-time PCR(RT-qPCR)
  • Digital droplet PCR (ddPCR)
Genotyping

Used to stratify patients based on genetic profiles and predict their responses to therapies.

  • Amplicon Sanger sequencing

  • Amplicon NGS
  • TaqMan assays
  • End-point PCR

Protein Analysis

Identifies protein biomarkers for disease diagnosis, prognosis, and monitoring treatment efficacy.

  • Enzyme-linked immunosorbent assay (ELISA)

  • Meso Scale Discovery (MSD)
  • Westen blotting (Jess)
  • Flow Cytometry
  • LC/MS/MS (coming soon)

Metabolomics

Provides insights into metabolic pathways and identifies metabolic biomarkers related to disease and treatment response.

  • LC/MS/MS (coming soon)

Epigenetic Analysis

Identifies epigenetic biomarkers that can influence gene expression and disease outcomes.

  • Bisulfite sequencing

  • Chromatin immunoprecipitation (ChIP) (coming soon)
  • Methylation-specific PCR

Immunoassays

Identifies immune-related biomarkers for diseases, especially in immunotherapy and infectious diseases.

  • ELISA
  • MSD
  • Flow Cytometry

Cytogenetics

Identifies chromosomal biomarkers related to cancer and genetic disorders.

  • Fluorescence in situ hybridization (FISH) (coming soon)

  • Karyotyping (coming soon)

Phenotyping

Used for immunophenotyping to identify and classify different cell types, particularly in immunology and oncology, and to assess cellular responses to treatments.

  • Flow Cytometry

Microbiomes Analysis

Identifies microbiome-related biomarkers that can impact health and treatment outcomes.

  • 16S rRNA sequencing

  • metagenomic sequencing

Have Questions?

We are dedicated to timely, high-quality service from the start of your project to the finish. Send us a quick message with your questions to find out what Avance can do for you.

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